Phosphoric Acid → HCID 67544534, compound

Participants

Reaction Conditions

Reaction Steps

33.82 g (125.6 mmol) of the 4-{hydroxy(4-methoxyphenyl)methyl}-3-(hydroxymethyl)benzonitrile prepared in step 2 was dissolved in 150 ml of ethylacetate, and 150 ml of a 85% aqueous solution of phosphoric acid was added at room temperature. The mixture was raised to 80° C. and stirred for 3 hrs. The reaction mixture was then cooled again to room temperature, and washed with water and saturated NaCl solution. An organic layer was dried over anhydrous magnesium sulfate, and filtered. The solvent was evaporated under reduced pressure. The residue was treated with 2-propanol to afford 18.0 g of a white solid (yield: 57%).

Provenance & Evidence