HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Difluoro-2-phenylethanol → (2-((6-Bromohexyl)oxy)-1,1-difluoroethyl)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Difluoro-2-phenylethanol | HCID 9793891 | — |
| Reactant | {4-((6-Bromohexyl)oxy]-3,3-difluorobutyl}benzene | HCID 67246468 | — |
| Product | (2-((6-Bromohexyl)oxy)-1,1-difluoroethyl)benzene | HCID 67245921 | 78% |
Reaction Steps
Obtained from Intermediate 6 (6.88 g, 43.5 mmol) by the procedure described in Intermediate 3. Purification by column chromatography with silica gel and n-hexane/ethyl acetate (10:1) as eluent gave the title compound (10.9 g, 78%) as oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08242177B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-7b01e0f342864953be621e60e31b27d6 |
| Source note | uspto-grants-2012_08 |