Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → Ethyl (2E)-4,4-difluoro-4-phenylbut-2-enoate

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Reaction Conditions

Reaction Steps

Intermediate 19 (0.88 g, 5.64 mmol) was dissolved in THF (12 mL) and (carbethoxymethylene)triphenylphosphorane (1.96 g, 5.64 mmol) was then added. The solution was stirred at 50° C. for 12 hours. The mixture was concentrated and the residue was purified by column chromatography on silica gel using n-hexane/AcOEt (5:1) as eluent. The title compound was obtained (1.10 g, 89%) as pale yellow oil.

Provenance & Evidence