Ethyl (2E)-4,4-difluoro-4-phenylbut-2-enoate → Ethyl 4,4-difluoro-4-phenylbutanoate

Participants

Reaction Steps

A solution of Intermediate 20 (1 g, 4.42 mmol) in methanol (20 mL) was hydrogenated in the presence of palladium on charcoal (10 mg, 10%) for 3 hours. The mixture was then filtered over Celite and the solvent removed under reduced pressure. The residue (0.91 g) was used in the next step without further purification.

Provenance & Evidence