2,2-Difluoro-4-phenylbutan-1-ol → 2,2-Difluoro-2-(m-tolyl)ethanol

HRID 885538Notes

Reaction equation

HRID 885538 reaction equation
[F:1][C:2]([F:15])([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[CH:9]=1)[C:3](OCC)=[O:4].FC(F)(CCC1C=CC=CC=1)CO>>[F:1][C:2]([F:15])([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[CH:9]=1)[CH2:3][OH:4]

Participants

3

Reactant 2

HCID 184257752,2-Difluoro-4-phenylbutan-1-olHCID 62394138Ethyl difluoro(3-methylphenyl)acetate

Product 1

HCID 672459192,2-Difluoro-2-(m-tolyl)ethanol

Procedure

Obtained from Intermediate 28 (9.5 g, 40 mmol) by the procedure described in Intermediate 2. The title compound was obtained (5.55 g, 80%) as oil.

Sources & evidence

ORD record
ord-2fb2a175e8de4ff5abdfd927db8f8cff
Source dataset
uspto-grants-2012_08
Patent number
US08242177B2

Reaction notes

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