HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Difluoro-2-(m-tolyl)ethanol → 1-{2-[(6-Bromohexyl)oxy]-1,1-difluoroethyl}-3-methylbenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Difluoro-2-(m-tolyl)ethanol | HCID 67245919 | — |
| Reactant | {4-((6-Bromohexyl)oxy]-3,3-difluorobutyl}benzene | HCID 67246468 | — |
| Product | 1-{2-[(6-Bromohexyl)oxy]-1,1-difluoroethyl}-3-methylbenzene | HCID 67245676 | 100% |
Reaction Steps
Obtained from Intermediate 29 (5.55 g, 32.2 mmol) by the procedure described in Intermediate 3. Purification by column chromatography with silica gel and n-hexane/ethyl acetate (from pure n-hexane to 10:1) as eluent gave the title compound (10.99 g, 100%) as oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08242177B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-0a8068abfa23402595c424cb98fea254 |
| Source note | uspto-grants-2012_08 |