HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl (2E)-4,4-difluoro-4-phenylbut-2-enoate → Ethyl (2E)-4,4,5,5-tetrafluoro-6-{[(2E)-3-phenylprop-2-en-1-yl]oxy}-hex-2-enoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl (2E)-4,4-difluoro-4-phenylbut-2-enoate | HCID 67244021 | — |
| Reactant | 2,2,3,3-Tetrafluoro-4-{[(2E)-3-phenylprop-2-en-1-yl]oxy}butanal | HCID 86658310 | — |
| Product | Ethyl (2E)-4,4,5,5-tetrafluoro-6-{[(2E)-3-phenylprop-2-en-1-yl]oxy}-hex-2-enoate | HCID 86658309 | 70% |
Reaction Steps
Obtained from Intermediate 38 (1.37 g, 4.96 mmol) by the procedure described in Intermediate 20. Purification by column chromatography with silica gel using n-hexane/ethyl acetate (15:1) as eluent gave the title compound (1.2 g, 70%) as oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08242177B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-d36eb2c96e394d70be84084ad6b5260e |
| Source note | uspto-grants-2012_08 |