2,2-Difluoro-4-phenylbutan-1-ol → 2-(3-Bromophenyl)-2,2-difluoroethanol

HRID 885546Notes

Reaction equation

HRID 885546 reaction equation
C([O:3][C:4](=O)[C:5]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([Br:14])[CH:9]=1)([F:7])[F:6])C.FC(F)(CCC1C=CC=CC=1)CO>>[Br:14][C:10]1[CH:9]=[C:8]([C:5]([F:6])([F:7])[CH2:4][OH:3])[CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 184257752,2-Difluoro-4-phenylbutan-1-olHCID 53419381Ethyl 2-(3-bromophenyl)-2,2-difluoroacetate

Product 1

HCID 672463332-(3-Bromophenyl)-2,2-difluoroethanol

Procedure

Obtained from Intermediate 48 (21.1 g, 75.8 mmol) by the procedure described in Intermediate 2. The title compound was obtained (17.2 g, 96%) as oil.

Sources & evidence

ORD record
ord-b5015aeb375948a7829e37f434b381c5
Source dataset
uspto-grants-2012_08
Patent number
US08242177B2

Reaction notes

Loading…