反应详情

To a suspension of Intermediate 76 (0.30 g, 1.40 mol) in ethanol (4 mL) was added a solution of 35% sodium hydroxide (1 mL). The mixture was stirred at room temperature for 2 hours. The crude reaction was diluted with methylene chloride (50 mL), washed with water (1×30 ML) and 1N hydrochloric acid (2×30 mL), dried (Na2SO4), and the solvent removed under reduced pressure. The title compound was obtained (0.22 g, 89%) as orange oil, and was used in the next step without further purification.

1. customThe crude reaction
2. washwashed with water (1×30 ML) and 1N hydrochloric acid (2×30 mL)
3. dry with materialdried (Na2SO4)
4. customthe solvent removed under reduced pressure