HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Difluoro-3-phenylpropan-1-ol → 6-Bromohexyl 2,2-difluoro-3-phenylpropyl ether
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Difluoro-3-phenylpropan-1-ol | HCID 57577071 | — |
| Reactant | 1-(2-[(6-Bromohexyl)oxy]-1,1-difluoroethyl)-3-methoxybenzene | HCID 67245384 | — |
| Product | 6-Bromohexyl 2,2-difluoro-3-phenylpropyl ether | HCID 67244815 | 36% |
Reaction Steps
Obtained from Intermediate 91 (0.75 g, 4.36 mmol) by the procedure described in Intermediate 69. Purification by column chromatography with silica gel eluting with n-hexane/ethyl acetate (from pure n-hexane to 40:1) gave the title compound (0.53 g, 36%) as oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08242177B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-5b1de8058e12463194668f72b7064b14 |
| Source note | uspto-grants-2012_08 |