HRID885623

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7841

Allyl bromide

C3H5Br

HCID441290

Rocuronium

C32H53N2O4+

PRODUCTS

产物

HCID441351

Rocuronium bromide

C32H53BrN2O4

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Rocuronium bromide was synthesised using conventional chemistry from the reaction of 1.7 kg of Rocuronium and 1.21 L of allyl bromide in 17 L of DCM.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-798a1049c4404526af2e0016dffdee6d
来源数据集: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08242265B2
来源说明: uspto-grants-2012_08

反应SMILES

[CH3:1][C:2]([O:4][C@@H:5]1[C@@:9]2([CH3:30])[CH2:10][CH2:11][C@@H:12]3[C@@:17]4([CH3:29])[CH2:18][C@H:19]([N:23]5[CH2:28][CH2:27][O:26][CH2:25][CH2:24]5)[C@@H:20]([OH:22])[CH2:21][C@@H:16]4[CH2:15][CH2:14][C@H:13]3[C@@H:8]2[CH2:7][C@@H:6]1[N+:31]1([CH2:36][CH:37]=[CH2:38])[CH2:35][CH2:34][CH2:33][CH2:32]1)=[O:3].C([Br:42])C=C>C(Cl)Cl>[CH3:1][C:2]([O:4][C@@H:5]1[C@@:9]2([CH3:30])[CH2:10][CH2:11][C@@H:12]3[C@@:17]4([CH3:29])[CH2:18][C@H:19]([N:23]5[CH2:24][CH2:25][O:26][CH2:27][CH2:28]5)[C@@H:20]([OH:22])[CH2:21][C@@H:16]4[CH2:15][CH2:14][C@H:13]3[C@@H:8]2[CH2:7][C@@H:6]1[N+:31]1([CH2:36][CH:37]=[CH2:38])[CH2:32][CH2:33][CH2:34][CH2:35]1)=[O:3].[Br-:42]