Tert-Butylamine → 2-tert-Butylamino-4-[4-fluoro-phenylethynyl]pyrimidine

HRID 885640ノート

反応式

HRID 885640 の反応式
Cl[C:2]1[N:7]=[C:6]([C:8]#[C:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[CH:5]=[CH:4][N:3]=1.[C:17]([NH2:21])([CH3:20])([CH3:19])[CH3:18]>O>[C:17]([NH:21][C:2]1[N:7]=[C:6]([C:8]#[C:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[CH:5]=[CH:4][N:3]=1)([CH3:20])([CH3:19])[CH3:18]

参加物

4

反応物 2

HCID 6385Tert-ButylamineHCID 121652312-Chloro-4-[2-(4-fluorophenyl)ethynyl]pyrimidine

生成物 1

HCID 116087122-tert-Butylamino-4-[4-fluoro-phenylethynyl]pyrimidine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 2-chloro-4-(4-fluoro-phenylethynyl)-pyrimidine (1 equiv.) in tert-butylamine (0.2 M) is heated at 80° C. in a sealed tube for 24 h. The mixture is cooled to rt, diluted with water, and extracted with EtOAc. The organic layer is concentrated and the residue purified by column chromatography to provide the title compound.

後処理

  1. extractionextracted with EtOAc
  2. concentrationThe organic layer is concentrated
  3. customthe residue purified by column chromatography

出典と根拠

ORDレコード
ord-96122060928b44638d2d5b3bf0bc1c61
出典データセット
uspto-grants-2012_08
特許番号
US08242273B2

反応ノート

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