HCID 76155194, compound → HCID 76155193, compound

Participants

Reaction Steps

t-Butyl 3-(5-(benzyloxy)pyridin-2-yl)-1-(4-(4-(hydroxyamino)-4-oxobutyl)-phenylamino)-1-oxopropan-2-ylcarbamate (0.1 g, 0.19 mmol) was dissolved in DCM/TFA (v/v=1:1) (30 mL), and stirred at room temperature for 4 h (monitored by TLC). The solution was evaporated in vacuo to give Compound 5 (0.062 g, 61%). mp>300° C.; NMR (400 MHz in CDCl3, Bruker AVANCE-400): δ 1.75 (m, 2H, CH2), 1.95 (t, 2H, CH2, J=7.37 Hz), 2.52 (t, 2H, CH2, J=7.55 Hz), 3.16 (m, 2H, CH2), 4.30 (m, 1H, CH), 5.16 (s, 2H, OBn), 7.13 (d, 2H, Ar—H, J=8.06 Hz), 7.24 (d, 1H, Ar—H, J=8.47 Hz), 7.33-8.46 (m, 9H, Ar—H), 8.22 (br, 2H, NH2), 8.30 (m, 1H, NH), 8.64 (br, 1H, NH), 10.33 (br, 1H, OH), 10.36 (br, 1H, TFA).

Provenance & Evidence