HCID 87232360, compound → HCID 123919966, compound

Participants

Reaction Steps

A mixture of t-butyl 3-(5-(benzyloxy)pyridin-2-yl)-1-(4-(hydroxyl-carbamoyl)benzylamino)-1-oxopropan-2-ylcarbamate (Compound 7) (0.26 g, 0.5 mmol) and 26 mg of 10% Pd/C in 2 mL of methanol was vigorously stirred under H2 for 4 h at room temperature and then filtered through Celite. The solvent was evaporated. The residue was purified by chromatography to give oily Compound 9 (0.16 g, 73%). NMR (400 MHz in CDCl3, Bruker AVANCE-400) : 1.28 (s, 9H, Boc), 3.15 (m, 2H, CH2), 4.28 (t, 2H, CH2, J=5.12 Hz), 4.36 (m, 1H, CH), 7.05-7.25 (m, 4H, Ar—H), 7.64-7.84 (m, 3H, Ar—H), 8.23 (br, 1H, NH), 8.51 (br, 1H, NH), 10.18 (br, 1H, NH), 11.16 (br, 1H, OH).

Provenance & Evidence