Trifluoroacetic acid → HCID 86659505, compound

Participants

Reaction Steps

A solution of tert-butyl1-(4-(hydroxycarbamoyl)benzylamino)-3-(5-hydroxypyridin-2-yl)-1-oxopropan-2-ylcarbamate (0.10 g, 0.19 mmol) with 1 mL of TFA in 10 mL of CH2Cl2 (25 mL) was stirred for 4 h at room temperature. The solvent was evaporated (monitored by TLC). The residue was purified by chromatography to give oily Compound 10 (0.045 g, 71%). NMR (400 MHz in CDCl3, Bruker AVANCE-400): δ 3.08 (m, 2H, CH2), 4.20 (m, 2H, CH2), 4.36 (m, 1H, CH), 7.08-7.28 (m, 4H, Ar—H), 7.62-7.70 (m, 2H, Ar—H), 7.82-7.88 (m, 1H, Ar—H), 8.96 (m, 2H, NH2), 9.13 (br, 1H, NH), 9.97 (br, 1H, NH), 11.15 (br, 1H, OH).

Provenance & Evidence