Hydrochloric Acid → HCID 24872021, compound

Participants

Reaction Steps

To this solution was added 569.5 g of 1% hydrochloric acid and mixed, and liquid-partitioning was caused. An organic layer obtained by liquid-partitioning was washed with 262.5 g of a 5% sodium hydrogen carbonate aqueous solution, further washed with 262.5 g of water, then, 1652.8 g of a toluene solution containing 349.7 g (1.552 mol) of 3-tert-butoxycarbonyl-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2-one was obtained. The yield with respect to 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2-one was 99.4%.

Provenance & Evidence