Benzophenone imine → 3-Bromo-2-chloro-5-fluoroaniline

Temperature

85 °C

To a sealable glass tube was charged 1,3-dibromo-2-chloro-5-fluorobenzene (12.52 g, 43.4 mmol), benzophenone imine (8.26 g, 45.6 mmol), sodium tert-butoxide (6.26 g, 65.1 mmol), and toluene (100 mL). The resulting mixture was thoroughly sparged with Argon, followed by the addition of Pd2(dba)3 (0.398 g, 0.434 mmol) and (S)-BINAP (0.81 g, 1.3 mmol), and follow by another Argon sparge. The reaction tube was sealed and heated to 85° C. in an oil bath and maintained overnight. The reaction was allowed to cool to room temperature and quenched with water (20 mL). The resulting layers were partitioned and separated. The organic phase was concentrated and assayed to be a mixture of mono- and bis-aminated products (˜4:1 by HPLC area at 220 nm). The residue was dissolved in THF (70 mL), treated with aqueous 3.0 M HCl (20 mL) at room temperature for 1 hour and basified with saturated aqueous Na2CO3 solution (40 mL). The reaction mixture was allowed to partition and the layers were separated. The organic portion was separated, washed with brine, concentrated and the resulting residue was purified by flash chromatography (SiO2, 0-15% EtOAc in heptane) and 3-bromo-2-chloro-5-fluoroaniline was obtained as a light yellow solid (6.82 g, 30.4 mmol): LCMS(m/z): not ionized (MH+), tR=0.95 minute; 1H NMR (CDCl3, 300 MHz) δ 4.32 (br s, 2H), 6.44 (dd, J=9.8, 2.8 Hz, 1H), 6.77 (dd, J=7.9, 2.6 Hz, 1H).

1. customThe resulting mixture was thoroughly sparged with Argon
2. customsparge
3. customThe reaction tube was sealed
4. temperaturemaintained overnight
5. temperatureto cool to room temperature
6. customquenched with water (20 mL)
7. customThe resulting layers were partitioned
8. customseparated
9. concentrationThe organic phase was concentrated
10. additiona mixture of mono- and bis-aminated products (˜4:1 by HPLC area at 220 nm)
11. dissolutionThe residue was dissolved in THF (70 mL)
12. additiontreated with aqueous 3.0 M HCl (20 mL) at room temperature for 1 hour
13. customto partition
14. customthe layers were separated
15. customThe organic portion was separated
16. washwashed with brine
17. concentrationconcentrated
18. customthe resulting residue was purified by flash chromatography (SiO2, 0-15% EtOAc in heptane)

ORD record

ord-132a138a52ed4889a23154abd9e391f7

Source dataset

uspto-grants-2012_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08242260B2