Tetrahydrofuran → HCID 59550253, compound

Participants

Reaction Conditions

Reaction Steps

2.16 g of (R)-3-hydroxy-tetradecanenitrile, 1.93 ml of dihydropyran and 20 ml of tetrahydrofuran were placed in a reactor and stirred, and 266 mg of pyridinium p-toluenesulfonate was added thereto, heated to 50° C., and stirred for about 2 hours. The mixture was cooled to room temperature, 30 ml of water and 30 ml of hexane were added thereto, and stirred vigorously for 5 minutes. The resulting mixture was allowed to undergo phase separation and the aqueous layer was removed. The organic layer was dried over anhydrous magnesium sulfate and concentrated under a reduced pressure, to give 2.97 g of the title compound (yield: 100%) as an oil.

Provenance & Evidence