Sodium Bicarbonate → tert-Butyl (E)-3-(5-formyl-pyridin-2-yl)-acrylate

Participants

Reaction Steps

A mixture of (E)-3-(5-dimethoxymethyl-pyridin-2-yl)-acrylic acid tert-butyl ester (1.76 mg, 6.30 mmol) in THF (30 ml) and 1 M HCl (25 ml) was stirred for 4 hours at room temperature, then brought to basic conditions with a 5% NaHCO3 solution and extracted twice with Et2O. The pooled organic phases were dried over Na2SO4 and evaporated in vacuo to dryness to give 1.45 g of (E)-3-(5-formyl-pyridin-2-yl)-acrylic acid tert-butyl ester as a white solid.

Provenance & Evidence