Potassium Carbonate → 3-Chloro-5-(4-methyl-piperazin-1-yl)-benzonitrile

HRID 885844Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 885844
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8](F)[CH:9]=1)[C:5]#[N:6].[CH3:11][N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([N:15]2[CH2:16][CH2:17][N:12]([CH3:11])[CH2:13][CH2:14]2)[CH:9]=1)[C:5]#[N:6]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 531671-MethylpiperazineHCID 27348413-Chloro-5-fluorobenzonitrile

Produkt 1

HCID 591389873-Chloro-5-(4-methyl-piperazin-1-yl)-benzonitrileAusbeute 65,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
140 °C

Versuchsvorschrift

A mixture of 3-chloro-5-fluoro-benzonitrile (1 g, 6.45 mmol), 1-methyl-piperazine (0.715 ml, 6.45 mmol), and K2CO3 (2.64 g, 19.3 mmol) in DMF (5 ml) was heated to 140° C. for 40 min in a microwave apparatus. The resulting slurry was filtered and the solvent was removed in vacuo to give 1 g of 3-chloro-5-(4-methyl-piperazin-1-yl)-benzonitrile. The crude reaction mixture was used in the next step without any further purification.

Aufarbeitung

  1. filtrationThe resulting slurry was filtered
  2. customthe solvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-58c40f4ecb7a48bb88aafb20ba0c1bc2
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08242175B2

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