Ether hydrochloride → 1-[(2R,6S)-2,6-Dimethylpiperazin-1-yl]ethan-1-one hydrochloride

Participants

Reaction Steps

(3S,5R)-4-Acetyl-3,5-dimethyl-piperazine-1-carboxylic acid tert-butyl ester (450 mg, 1.75 mmol) was dissolved in DCM (10 ml) and acidified with HCl/Et2O. The mixture was stirred at room temperature for two days. The resulting solid was filtered to give 190 mg of 1-((2R,6S)-2,6-dimethyl-piperazin-1-yl)ethanone hydrochloride. The mother liquors were treated with HCl/Et2O for 4 h and the resulting solid was filtered to give additional 43 mg of the title compound as hydrochloric salt.

Provenance & Evidence