反应详情

A mixture of 1-(4-piperazin-1-yl-phenyl)-ethanone (513 mg, 2.51 mmol), BOC2O (820 mg, 3.76 mmol) and TEA (0.698 ml, 5.02 mmol) in DCM (20 ml) was stirred at room temperature overnight. The resulting solution was concentrated in vacuo and then partitioned between water and AcOEt. The organic phase was dried over Na2SO4, evaporated in vacuo and the crude reaction mixture was purified by column chromatography (eluent: petroleum ether/AcOEt) to give 701 mg of 4-(4-acetyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester.

1. concentrationThe resulting solution was concentrated in vacuo
2. custompartitioned between water and AcOEt
3. dry with materialThe organic phase was dried over Na2SO4
4. customevaporated in vacuo
5. customthe crude reaction mixture
6. customwas purified by column chromatography (eluent: petroleum ether/AcOEt)