Potassium Carbonate → HCID 62492717, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-chloro-2-fluoro-benzonitrile (500 mg, 3.21 mmol), K2CO3 (1.32 g, 9.64 mmol) and 1-methyl-piperazine (482 mg, 4.81 mmol) in DMSO (6.4 ml) was stirred at 100° C. for 6 h and then partitioned between water and Et2O. The organic phase was dried over Na2SO4 and evaporated in vacuo. The crude mixture was purified by column chromatography (eluent: DCM/MeOH/NH4OH 98:2:0.1) to give 660 mg of 5-chloro-2-(4-methyl-piperazin-1-yl)-benzonitrile.

Provenance & Evidence