Acetic Acid → HCID 67050422, compound

HRID 885867Notes

Reaction equation

HRID 885867 reaction equation
[N:1]1([C:7]2[CH:12]=[CH:11][C:10]([C:13](=[O:15])[CH3:14])=[CH:9][CH:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[O:16]([C:18]#[N:19])[Na].CC(O)=O>C(Cl)Cl>[C:13]([C:10]1[CH:9]=[CH:8][C:7]([N:1]2[CH2:6][CH2:5][N:4]([C:18]([NH2:19])=[O:16])[CH2:3][CH2:2]2)=[CH:12][CH:11]=1)(=[O:15])[CH3:14]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 97269Piperazin-4-ylacetophenoneHCID 178418852HCID 178418852, compound

Product 1

HCID 67050422HCID 67050422, compoundYield 111.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-(4-Piperazin-1-yl-phenyl)-ethanone (500 mg, 2.45 mmol) was dissolved in DCM (20 ml) and NaOCN (318.6 mg, 4.90 mmol) and AcOH (0.28 ml, 4.90 mmol) were added to the resulting solution. The mixture was stirred at room temperature for 36 h and the resulting precipitate was filtered off, washed with DCM and water to give 675 mg of 4-(4-acetyl-phenyl)-piperazine-1-carboxylic acid amide (crude compound was used without further purification in the next step).

Workup

  1. filtrationthe resulting precipitate was filtered off
  2. washwashed with DCM and water

Sources & evidence

ORD record
ord-8acabca317d34bb28770e06e6349828b
Source dataset
uspto-grants-2012_08
Patent number
US08242175B2

Reaction notes

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