1-Acetylpiperazine → HCID 24756557, compound

HRID 885875Notes

Reaction equation

HRID 885875 reaction equation
O1CCCCC1[O:7][NH:8][C:9](/[CH:11]=[CH:12]/[C:13]1[CH:18]=[CH:17][C:16](/[CH:19]=[CH:20]/[C:21]([C:23]2[CH:34]=[CH:33][C:26]([CH2:27]OS(C)(=O)=O)=[CH:25][CH:24]=2)=[O:22])=[CH:15][CH:14]=1)=[O:10].ClCC1C=CC(C(=O)/C=C/C2C=CC(/C=C/C(NOC3CCCCO3)=O)=CC=2)=CC=1.[N:65]1([C:71](=[O:73])[CH3:72])[CH2:70][CH2:69][NH:68][CH2:67][CH2:66]1>>[C:71]([N:65]1[CH2:70][CH2:69][N:68]([CH2:27][C:26]2[CH:25]=[CH:24][C:23]([C:21](=[O:22])/[CH:20]=[CH:19]/[C:16]3[CH:17]=[CH:18][C:13](/[CH:12]=[CH:11]/[C:9]([NH:8][OH:7])=[O:10])=[CH:14][CH:15]=3)=[CH:34][CH:33]=2)[CH2:67][CH2:66]1)(=[O:73])[CH3:72]

Participants

4

Reactant 3

HCID 837951-AcetylpiperazineHCID 59312563HCID 59312563, compoundHCID 86641368HCID 86641368, compound

Product 1

HCID 24756557HCID 24756557, compound

Procedure

The product was obtained starting from a mixture of methanesulfonic acid 4-((E)-3-{4-[(E)-2-(tetrahydro-pyran-2-yloxycarbamoyl)-vinyl]-phenyl}-acryloyl)-benzyl ester and (E)-3-{4-[(E)-3-(4-chloromethyl-phenyl)-3-oxo-propenyl]-phenyl}-N-(tetrahydro-pyran-2-yloxy)-acrylamide (both obtained as described in Preparation 5) and 1-piperazin-1-yl-ethanone, following the experimental procedure described for Example 28. The title compound was obtained as its hydrochloride salt.

Workup

  1. customThe product was obtained
  2. customboth obtained

Sources & evidence

ORD record
ord-1950f50c838e4572a912c1bdf3609aaf
Source dataset
uspto-grants-2012_08
Patent number
US08242175B2

Reaction notes

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