HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (E)-3-(5-formyl-pyridin-2-yl)-acrylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl (E)-3-(5-formyl-pyridin-2-yl)-acrylate | HCID 44819897 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (E)-3-(5-formyl-pyridin-2-yl)-acrylic acid | HCID 86641373 | 143.5% |
Reaction Steps
A mixture of (E)-3-(5-formyl-pyridin-2-yl)-acrylic acid tert-butyl ester (described in Example 11 STEP A-D, 250 mg, 1.07 mmol) and TFA (1 ml) in DCM (4 ml) was stirred at room temperature for 6 h. The solvent was then removed in vacuo and the solid was triturated with Et2O to give 272 mg of (E)-3-(5-formyl-pyridin-2-yl)-acrylic acid as its trifluoroacetate salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08242175B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-b5d3b44949884cd2ab8a28252e40d0d8 |
| Source note | uspto-grants-2012_08 |