HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 885936Generated: October 31, 2026
3-Chloro-1-propanol → 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propan-1-ol
https://huagongshe.com/reaction/885936
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Chloro-1-propanol | HCID 12313 | — |
| Reactant | 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole | HCID 2774010 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propan-1-ol | HCID 67187127 | — |
Reaction Steps
The title compound was prepared from pyrazole-4-boronic acid pinacol ester and 3-chloro-1-propanol according to Method AC (heating to 90° C. for 6 days before addition of further 3-chloro-1-propanol and triethylamine, and heating to 90° C. for a further 3 days) and was isolated as a brown gum (quantitative). LCMS (ES+) 253 (M+H)+, RT 2.53 minutes (Method 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08242116B2 |
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| Source dataset | uspto-grants-2012_08 |
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| ORD ID | ord-41401df9190a42388ddb636c5410bcab |
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| Source note | uspto-grants-2012_08 |
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