HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 885937Generated: October 31, 2026
Piperidine, 1-(2-chloroethyl)-, hydrochloride → 1-[2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethyl]piperidine
https://huagongshe.com/reaction/885937
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidine, 1-(2-chloroethyl)-, hydrochloride | HCID 74826 | — |
| Reactant | 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole | HCID 2774010 | — |
| Product | 1-[2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethyl]piperidine | HCID 59320389 | — |
Reaction Steps
The title compound was prepared from pyrazole-4-boronic acid pinacol ester and 1-(2-chloroethyl)piperidine hydrochloride according to Method AC (heating to 90° C. for 6 days before addition of further 1-(2-chloroethyl)piperidine hydrochloride, and heating to 90° C. for a further 3 days) and was isolated as a brown gum (69%). LCMS (ES+) 305 (M+H)+, RT 1.91 minutes (Method 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08242116B2 |
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| Source dataset | uspto-grants-2012_08 |
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| ORD ID | ord-be10d9de99ac49fe9d65c7643f8c1669 |
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| Source note | uspto-grants-2012_08 |
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