反应详情

4-Formyl-3-hydroxybenzoic acid (5 g, 30 mmol) was suspended in methanol (70 mL), and treated with thionyl chloride (3.29 mL 45 mmol) dropwise. The mixture was heated to reflux overnight. Concentrated to dryness, and 50 mL of toluene was added, and concentrated again. The residue was recrystallized from ethyl acetate-hexane. A total of 4.8 g (85%) of methyl 4-formyl-3-hydroxybenzoate was obtained.

1. temperatureThe mixture was heated
2. temperatureto reflux overnight
3. concentrationConcentrated to dryness, and 50 mL of toluene
4. additionwas added
5. concentrationconcentrated again
6. customThe residue was recrystallized from ethyl acetate-hexane