Cesium carbonate → HCID 58204348, compound

HRID 886061Notes

Reaction equation

HRID 886061 reaction equation
[I:1][C:2]1[N:3]=[CH:4][NH:5][CH:6]=1.C([O-])([O-])=O.[Cs+].[Cs+].[CH3:13][C:14]1([CH3:17])[CH2:16][O:15]1>>[I:1][C:2]1[N:3]=[CH:4][N:5]([CH2:13][C:14]([CH3:17])([OH:15])[CH3:16])[CH:6]=1

Participants

4

Reactant 3

HCID 10796Cesium carbonateHCID 11208Isobutylene oxideHCID 178506559HCID 178506559, compound

Product 1

HCID 58204348HCID 58204348, compoundYield 71%

Conditions

Temperature
120 °C

Procedure

A mixture of 4-iodo-1H-imidazole, Cs2CO3 in 2,2-dimethyl oxirane was stirred at 120° C. for 20 min under irradiation with microwave. The reaction mixture was concentrated, and purified to give 1-(4-iodo-1H-imidazol-1-yl)-2-methylpropan-2-ol (Yield=71%). LC-MS: m/z=266 [M+H+] 1H NMR (CDCl3, 400 MHz): δ7.36 (s, 1H), 7.06 (s, 1H), 3.84 (s, 2H), 1.22 (s, 6H).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. custompurified

Sources & evidence

ORD record
ord-fb6e5b9b6bf3490d9902e438069b9527
Source dataset
uspto-grants-2012_08
Patent number
US08242104B2

Reaction notes

Loading…