Methanol → 9-Chloro-5,6-dihydrobenzo[f][1,2,4]triazolo[1,5-d][1,4]oxazepine-2-carboxylic acid

참여 물질

역할	이름	HCID	투입량
반응물	Methanol	HCID 887	—
반응물	Water	HCID 962	—
반응물	Lithium Hydroxide	HCID 3939	—
반응물	Methyl-9-chloro-5,6-dihydrobenzo[f][1,2,4]triazolo[1,5-d][1,4]oxazepine-2-carboxylate	HCID 58204850	—
용매	Tetrahydrofuran	HCID 8028	—
생성물	9-Chloro-5,6-dihydrobenzo[f][1,2,4]triazolo[1,5-d][1,4]oxazepine-2-carboxylic acid	HCID 58204586	89%

반응 조건

온도	25 °C

반응 단계

Methyl-9-chloro-5,6-dihydrobenzo[f][1,2,4]triazolo[1,5-d][1,4]oxazepine-2-carboxylate (0.144 g, 0.515 mmol) was dissolved in 3:2:1 THF:MeOH:H2O (5.0 mL), and treated with 4 N aqueous LiOH (0.644 mL). The mixture was stirred for 30 min at 25° C. The reaction was quenched with 1 N aq. HCl (10 mL) and the solution was extracted with EtOAc (3×20 mL). The combined organic extracts were dried with Na2SO4 and concentrated in vacuo to give 9-Chloro-5,6-dihydrobenzo[f][1,2,4]triazolo[1,5-d][1,4]oxazepine-2-carboxylic acid (89% yield)

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08242104B2
출처 데이터셋	uspto-grants-2012_08
ORD ID	ord-0f3a372c5b8b4528ab7c85f8e768846b
출처 메모	uspto-grants-2012_08