2-chloro-1-(oxan-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-imidazole → 1-(Tetrahydro-2H-pyran-2-YL)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)-1H-imidazole

HRID 886248Notes

Reaction equation

HRID 886248 reaction equation
[H][H].Cl[C:4]1[N:5]([CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][O:19]2)[C:6]([B:9]2[O:13][C:12]([CH3:15])([CH3:14])[C:11]([CH3:17])([CH3:16])[O:10]2)=[CH:7][N:8]=1>[Pd]>[O:19]1[CH2:20][CH2:21][CH2:22][CH2:23][CH:18]1[N:5]1[C:6]([B:9]2[O:13][C:12]([CH3:15])([CH3:14])[C:11]([CH3:17])([CH3:16])[O:10]2)=[CH:7][N:8]=[CH:4]1

Participants

4

Reactant 2

HCID 455881562-chloro-1-(oxan-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-imidazoleHCID 178418361HCID 178418361, compound

Product 1

HCID 248800081-(Tetrahydro-2H-pyran-2-YL)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)-1H-imidazole

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

1-(Tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-imidazole was prepared by hydrogen with palladium reduction of 2-chloro-1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-imidazole.

Sources & evidence

ORD record
ord-1e31123b26fd4d67995338281db2b6ff
Source dataset
uspto-grants-2012_08
Patent number
US08242104B2

Reaction notes

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