HCID 24809784, compound → HCID 24809748, compound

Participants

Reaction Steps

A solution of 1,1,1-trifluoro-3-[(phenylmethyl)amino]-2-{[(phenylmethyl)amino]methyl}-2-propanol (8.15 g, 24.1 mmol) in ethanol (200 ml) was stirred under a hydrogen atmosphere over Pearlman's catalyst (500 mg) for 24 hours. The catalyst was filtered off and the filtrate concentrated under reduced pressure. The residue was redissolved in methanol and concentrated under reduced pressure to give an oil (4.825 g). This oil was redissolved in ethanol (200 ml) and stirred under a hydrogen atmosphere over Pearlman's catalyst (500 mg) for 24 hours. The catalyst was filtered off and the filtrate concentrated under reduced pressure to give the title compound (3.07 g) as an oil.

Provenance & Evidence