反应详情

5-amino-1-(4-fluorophenyl)-N-(3,3,3-trifluoro-2-hydroxy-2-{[(phenylmethyl)amino]methyl}propyl)-1H-pyrazole-4-carboxamide (20.47 g) was dissolved in ethanol (100 ml) and hydrogenated over 10% palladium on carbon (2 g). A small portion was filtered using celite to give an orange yellow solution and LC/MS analysis indicated complete reaction. Therefore the remainder of the suspension was then filtered and the orange yellow solution concentrated in vacuo to give a pale yellow solid. This was dried on the vacuum line overnight to give the title compound (14.64 g) as a white solid.

1. filtrationA small portion was filtered
2. customto give an orange yellow solution and LC/MS analysis
3. customreaction
4. filtrationTherefore the remainder of the suspension was then filtered
5. concentrationthe orange yellow solution concentrated in vacuo
6. customto give a pale yellow solid
7. customThis was dried on the vacuum line overnight