Ethanol → (S)-2-(Trifluoromethyl)-3-(benzylamino)propane-1,2-diol

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(S)-3,3,3-Trifluoro-2-hydroxy-2-{[(phenylmethyl)amino]methyl}propyl butanoate (0.32 g) was dissolved in 5M hydrochloric acid (5 ml) and ethanol (5 ml) and heated at 100° C. for 3 hours. After cooling, the ethanol was evaporated and the remaining aqueous was basified with 2M sodium hydroxide and extracted with ethyl acetate (2 times). The combined organics were dried using a hydrophobic frit and evaporated to give the title compound as a pale yellow oil (0.26 g).

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