(S)-2-(Trifluoromethyl)-3-(benzylamino)propane-1,2-diol → 1,2-Propanediol, 2-(aminomethyl)-3,3,3-trifluoro-, (2S)-

(S)-3,3,3-Trifluoro-2-{[(phenylmethyl)amino]methyl}-1,2-propanediol (160 mg) was dissolved in methanol (1.5 ml) and hydrogenated using 10% palladium on carbon as the catalyst and the H-cube (Thales) as the hydrogen source. The solvent was carefully evaporated to give a pinkish volatile oil (112 mg) which by 1H NMR still contained 13% starting material. Therefore this was re-dissolved in methanol (2 ml) and re-hydrogenated using the H-cube. The solvent was evaporated to give the title compound as a pink/brown oil (93 mg).

1. customThe solvent was carefully evaporated

ORD record

ord-bbe503b585a74c9e892b0738621e6d6f

Source dataset

uspto-grants-2012_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08247377B2