Lithium Hydroxide → HCID 59487505, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 2,6-bis(difluoromethyl)benzoate (205 mg) in methanol (3 ml) was added a solution of lithium hydroxide (48 mg) in methanol (3 ml). It was stirred at 21° C. and the initial oily suspension slowly cleared over ca. 2 hours but insoluble material remained. It was stirred for a total of 20 hours and then evaporated to dryness. It was partitioned between ethyl acetate (10 ml) and water (10 ml), washed with ether (10 ml), acidified with 2M hydrochloric acid and extracted with ethyl acetate (2×10 ml). This was washed with water (10 ml) and saturated brine (10 ml), dried over sodium sulphate and evaporated to give the title compound (146 mg).

Provenance & Evidence