1-Methanesulfonylpiperazine hydrochloride → 2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[2,3-d]pyrimidine

HRID 886740Notes

Reaction equation

HRID 886740 reaction equation
Cl.[CH3:2][S:3]([N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)(=[O:5])=[O:4].[Cl:12][C:13]1[N:14]=[C:15]([N:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)[C:16]2[CH:21]=[C:20]([CH:22]=O)[S:19][C:17]=2[N:18]=1>>[Cl:12][C:13]1[N:14]=[C:15]([N:24]2[CH2:25][CH2:26][O:27][CH2:28][CH2:29]2)[C:16]2[CH:21]=[C:20]([CH2:22][N:9]3[CH2:10][CH2:11][N:6]([S:3]([CH3:2])(=[O:5])=[O:4])[CH2:7][CH2:8]3)[S:19][C:17]=2[N:18]=1

Participants

3

Reactant 2

HCID 162656121-Methanesulfonylpiperazine hydrochlorideHCID 568338442-Chloro-4-morpholinothieno[2,3-d]pyrimidine-6-carbaldehyde

Product 1

HCID 568339462-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[2,3-d]pyrimidine

Procedure

Reaction between 1-methanesulfonyl-piperazine HCL salt and 2-chloro-4-morpholin-4-yl-thieno[2,3-d]pyrimidine-6-carbaldehyde 33 using General Procedure C yielded 2-chloro-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[2,3-d]pyrimidine.

Sources & evidence

ORD record
ord-fd027b4319744714affeb3e215a0b614
Source dataset
uspto-grants-2012_08
Patent number
US08247397B2

Reaction notes

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