Hydrochloric Acid → HCID 59499318, compound

Participants

Reaction Steps

18 mg (0.03 mmoles, 1 eq) of 5-{2-[3-(3,3-diphenyl-propyl)-3-(2-morpholin-4-yl-ethyl)-ureido]-thiazol-4-yl}-isoxazole-3-carboxylic acid ethyl ester (obtained in example 30) are dissolved in 1.5 mL of EtOH then 2 eq of 1 N NaOH are added to the solution. The mixture is stirred at room temperature for 3 hours prior to neutralisation at pH 5-6 with a 2 N HCl solution. The aqueous phase is extracted with AcOEt then the organic substances collected are washed with brine, dried over MgSO4 prior to evaporation to give 5-{2-[3-(3,3-diphenyl-propyl)-3-(2-morpholin-4-yl-ethyl)-ureido]-thiazol-4-yl}-isoxazole-3-carboxylic acid (obtained in example 32) (quantitative yield) in the form of a white solid.

Provenance & Evidence