反应详情

温度

60 °C

1.85 g (7.39 mmol, 1 eq) of 4 are introduced into 40 mL of EtOH. 14.8 mL (14.78 mmol, 2 eq) of 1 N sodium hydroxide are added and the mixture is stirred for 45 min at 60° C. The reagent dissolves completely while hot. The ethanol is concentrated, the residue is taken up in the water and AcOEt is added. The aqueous phase is acidified to pH 3, then extracted with AcOEt. The organic phase is washed with brine, dried, filtered and concentrated (m=1.62 g, yield=99%).

1. dissolutionThe reagent dissolves completely while hot
2. concentrationThe ethanol is concentrated
3. additionis added
4. extractionextracted with AcOEt
5. washThe organic phase is washed with brine
6. customdried
7. filtrationfiltered
8. concentrationconcentrated (m=1.62 g, yield=99%)