Morpholine → HCID 25255960, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-(2-chloro-9-m-tolyl-9H-purin-6-yl)-pyrimidin-2-yl-amine (0.182 mmolmmol) in dimethyl acetamide (4 ml) was added morpholine (0.4 mmol). The reaction mix was heated on an oil bath maintained at 94° C. for 12 h. The reaction was monitored for the absence of the give 5-(2-chloro-9-m-tolyl-9H-purin-6-yl)-pyrimidin-2-yl-amine, by LC-MS. The crude material was directly loaded onto a preparative HPLC column and purified by chromatography to give the title compound. m/z: 389.2 [MH]+.

Provenance & Evidence