Hydrogen chloride-ethyl acetate → HCID 68578489, compound

HRID 886829Notes

Reaction equation

HRID 886829 reaction equation
[N:1]1([C:6]2[CH:23]=[CH:22][C:9]3[CH2:10][N:11](C(OC(C)(C)C)=O)[CH2:12][CH2:13][O:14][C:8]=3[CH:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.C(OCC)(=O)C.[ClH:30]>>[ClH:30].[ClH:30].[N:1]1([C:6]2[CH:23]=[CH:22][C:9]3[CH2:10][NH:11][CH2:12][CH2:13][O:14][C:8]=3[CH:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68579876HCID 68579876, compound

Product 1

HCID 68578489HCID 68578489, compoundYield 73.3%

Procedure

A solution of tert-butyl 8-(pyrrolidin-1-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (110 mg, 0.345 mmol) in 4N hydrogen chloride-ethyl acetate (2 ml) was stirred for 1 hr at room temperature, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (74.0 mg, 73.3%) as a solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and ether

Sources & evidence

ORD record
ord-baee1012e92146398ed810ea4203af52
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

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