HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen chloride-ethyl acetate → HCID 68578308, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Reactant | 1,1-Dimethylethyl 2,3-dihydro-9-(1-pyrrolidinyl)-1,4-benzoxazepine-4(5H)-carboxylate | HCID 68578644 | — |
| Product | HCID 68578308 | HCID 68578308 | 30.9% |
Reaction Steps
A solution of tert-butyl 9-(pyrrolidin-1-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (90.0 mg, 0.283 mmol) in 4N hydrogen chloride-ethyl acetate (3 ml) was stirred for 1 hr at room temperature, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (25.4 mg, 30.9%) as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247403B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-5da03bbad2b7415b8f0cf3510b4478d8 |
| Source note | uspto-grants-2012_08 |