Hydrogen chloride-ethyl acetate → 9-[4-(Trifluoromethyl)phenyl]-2,3,4,5-tetrahydro-1,4-benzoxazepine hydrochloride

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Reaction Steps

A mixture of tert-butyl 9-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (210 mg, 0.534 mmol), ethyl acetate (1 ml) and 4N hydrogen chloride-ethyl acetate solution (4 ml) was stirred for 1 hr at room temperature, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (143 mg, 81.3%) as a solid.

Provenance & Evidence