Hydrogen chloride-ethyl acetate → 9-(Pyridin-4-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepine dihydrochloride

Participants

Reaction Steps

A mixture of tert-butyl 9-(pyridin-4-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (109 mg, 0.334 mmol), ethyl acetate (1 ml) and 4N hydrogen chloride-ethyl acetate solution (4 ml) was stirred for 1 hr at room temperature, and the solvent was evaporated under reduced pressure. The residue was recrystallized from methanol to give the desired product (19.0 mg, 19.0%) as a solid.

Provenance & Evidence