Hydrogen chloride-ethyl acetate → 7-Phenyl-2,3,4,5-tetrahydro-1,4-benzoxazepine hydrochloride

Participants

Reaction Steps

A mixture of tert-butyl 7-phenyl-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (160 mg, 0.471 mmol), ethyl acetate (1 ml) and 4N hydrogen chloride-ethyl acetate solution (4 ml) was stirred for 1 hr at room temperature, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (112 mg, 91.1%) as a solid.

Provenance & Evidence