HCID 68580483, compound → HCID 68578177, compound

HRID 886911Notes

Reaction equation

HRID 886911 reaction equation
[C:1]1([C:6]2[C:16]3[O:15][CH2:14][CH2:13][N:12]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:11][C:10]=3[CH:9]=[CH:8][CH:7]=2)[CH2:5][CH2:4][CH2:3][CH:2]=1>[Pd].CO>[CH:1]1([C:6]2[C:16]3[O:15][CH2:14][CH2:13][N:12]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:11][C:10]=3[CH:9]=[CH:8][CH:7]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 1

HCID 68580483HCID 68580483, compound

Product 1

HCID 68578177HCID 68578177, compoundYield 92.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of tert-butyl 9-(cyclopenta-1-en-1-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (140 mg, 0.444 mmol) and 10% palladium on carbon (100 mg) in methanol (5 ml) was stirred under a hydrogen atmosphere for 12 hr. The reaction mixture was filtered, and the filtrate was concentrated to give the desired product (130 mg, 92.2%) as an oil.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-02dd74df82f74f1b920dfaea374d50e2
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

Loading…