Hydrogen chloride-ethyl acetate → 9-Isoxazol-4-yl-2,3,4,5-tetrahydro-1,4-benzoxazepine hydrochloride

Participants

Reaction Steps

A mixture of tert-butyl 9-isoxazol-4-yl-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (120 mg, 0.379 mmol), ethyl acetate (2 ml) and 4N hydrogen chloride-ethyl acetate solution (4 ml) was stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (13.3 mg, 13.9%) as a solid.

Provenance & Evidence