Pyrrolidine → HCID 68578725, compound

Participants

Reaction Steps

To a solution of 4-(tert-butoxycarbonyl)-2,3,4,5-tetrahydro-1,4-benzoxazepine-9-carboxylic acid (40.0 mg, 0.136 mmol), 1-hydroxybenzotriazole (18.4 mg, 0.136 mmol) and pyrrolidine (0.017 ml, 0.204 mmol) in DMF (1 ml) was added 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (52.2 mg, 0.272 mmol), and the mixture was stirred at room temperature for 12 hr. The reaction mixture was poured into water, and the mixture was extracted with ethyl acetate. The extract was washed with water and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give the desired product (42.0 mg, 89.2%) as an oil.

Provenance & Evidence