Morpholine → HCID 68578783, compound

Participants

Reaction Steps

To a solution of 4-(tert-butoxycarbonyl)-2,3,4,5-tetrahydro-1,4-benzoxazepine-9-carboxylic acid (125 mg, 0.426 mmol) and 1-hydroxybenzotriazole (57.6 mg, 0.426 mmol), morpholine (0.0743 ml, 0.852 mmol) in DMF (3 ml) was added 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (163 mg, 0.852 mmol), and the mixture was stirred at room temperature for 12 hr. The reaction mixture was poured into water, and the mixture was extracted with ethyl acetate. The extract was washed with water and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (hexane:ethyl acetate=1:2) to give the desired product (130 mg, 84.4%) as a solid.

Provenance & Evidence